Hypospadias and urethral abnormalities in Down syndrome

In the course of general medical evaluations of 149 children and adolescents (younger than 21 years of age) and 11 adults with Down syndrome, five of the 77 males were noted to have dorsal urethral duplications. In all instances, there proved to be a single urethral meatus. The second opening led in...

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Bibliographic Details
Published inClinical pediatrics Vol. 26; no. 1; p. 40
Main Authors Lang, D J, Van Dyke, D C, Heide, F, Lowe, P L
Format Journal Article
LanguageEnglish
Published United States 01.01.1987
Subjects
Abnormalities, Multiple
Adolescent
Adult
Child
Child, Preschool
Down Syndrome - complications
Humans
Hypospadias - complications
Hypospadias - pathology
Male
Urethra - abnormalities
Urethra - pathology
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Summary:In the course of general medical evaluations of 149 children and adolescents (younger than 21 years of age) and 11 adults with Down syndrome, five of the 77 males were noted to have dorsal urethral duplications. In all instances, there proved to be a single urethral meatus. The second opening led into a pit or blind channel, reflecting the presence of a distal hypospadias. In these five patients, laboratory studies were normal, nephrology histories were negative, and radiographic studies did not demonstrate any anatomic abnormalities of the urethra, ureters, or kidneys. These findings indicate that there is an increased occurrence of distal hypospadias in males with Down syndrome that may present with dorsal urethral duplications and/or glanular hypospadias.
ISSN:0009-9228
DOI:10.1177/000992288702600107