Expression, characterization and therapeutic efficacy of chimeric Fab of anti-idiotypic antibody NP30 against Schistosoma japonicum
► A human–mouse chimeric Fab of monoclonal anti-idiotypic antibody NP30 (chFab-NP30) against Schistosoma japonicum was constructed and expressed in E. coli. ► The purified chFab-NP30 inhibited the binding of parent NP30 to sera from schistosomiasis patients in a dose-dependent manner. ► Administrati...
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| Published in | Acta tropica Vol. 118; no. 2; pp. 159 - 164 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.05.2011
Elsevier |
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| Abstract | ► A human–mouse chimeric Fab of monoclonal anti-idiotypic antibody NP30 (chFab-NP30) against Schistosoma japonicum was constructed and expressed in E. coli. ► The purified chFab-NP30 inhibited the binding of parent NP30 to sera from schistosomiasis patients in a dose-dependent manner. ► Administration of the chimeric Fab in vivo increased the survival rate, reduced egg burdens and ameliorated organ pathology of mice with acute schistosomiasis. ► chFab-NP30 is a promising candidate to be used as a specific and efficient recombinant antibody against acute schistosomiasis japonica.
The murine monoclonal anti-idiotypic antibody NP30 is a promising therapeutic antibody against Schistosoma japonicum. However, the immunogenicity of murine NP30 limits its further study and application in humans. Here the chimeric Fab of NP30 (chFab-NP30) comprising the variable regions of murine NP30 and constant regions of human antibody was assembled. chFab-NP30 was expressed and purified as a soluble and functional protein. Administration of chFab-NP30 in vivo increased the survival rate, reduced egg burdens and ameliorated organ pathology of mice with acute schistosomiasis. Our study indicated that chFab-NP30 is a promising candidate to be used as a specific and efficient recombinant antibody against acute schistosomiasis japonica. Further studies on function mechanism of chFab-NP30 needs to be carried out in the future. |
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| AbstractList | The murine monoclonal anti-idiotypic antibody NP30 is a promising therapeutic antibody against Schistosoma japonicum. However, the immunogenicity of murine NP30 limits its further study and application in humans. Here the chimeric Fab of NP30 (chFab-NP30) comprising the variable regions of murine NP30 and constant regions of human antibody was assembled. chFab-NP30 was expressed and purified as a soluble and functional protein. Administration of chFab-NP30 in vivo increased the survival rate, reduced egg burdens and ameliorated organ pathology of mice with acute schistosomiasis. Our study indicated that chFab-NP30 is a promising candidate to be used as a specific and efficient recombinant antibody against acute schistosomiasis japonica. Further studies on function mechanism of chFab-NP30 needs to be carried out in the future. ► A human–mouse chimeric Fab of monoclonal anti-idiotypic antibody NP30 (chFab-NP30) against Schistosoma japonicum was constructed and expressed in E. coli. ► The purified chFab-NP30 inhibited the binding of parent NP30 to sera from schistosomiasis patients in a dose-dependent manner. ► Administration of the chimeric Fab in vivo increased the survival rate, reduced egg burdens and ameliorated organ pathology of mice with acute schistosomiasis. ► chFab-NP30 is a promising candidate to be used as a specific and efficient recombinant antibody against acute schistosomiasis japonica. The murine monoclonal anti-idiotypic antibody NP30 is a promising therapeutic antibody against Schistosoma japonicum. However, the immunogenicity of murine NP30 limits its further study and application in humans. Here the chimeric Fab of NP30 (chFab-NP30) comprising the variable regions of murine NP30 and constant regions of human antibody was assembled. chFab-NP30 was expressed and purified as a soluble and functional protein. Administration of chFab-NP30 in vivo increased the survival rate, reduced egg burdens and ameliorated organ pathology of mice with acute schistosomiasis. Our study indicated that chFab-NP30 is a promising candidate to be used as a specific and efficient recombinant antibody against acute schistosomiasis japonica. Further studies on function mechanism of chFab-NP30 needs to be carried out in the future. |
| Author | Xu, Jing Zhu, Yin-Chang Li, Yu-Hua Feng, Zhen-Qing Guan, Xiao-Hong Zhu, Xiao-Juan Dai, Yang Zheng, Jiang |
| Author_xml | – sequence: 1 givenname: Jing surname: Xu fullname: Xu, Jing organization: Key Lab of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 200029, China – sequence: 2 givenname: Xiao-Juan surname: Zhu fullname: Zhu, Xiao-Juan organization: Key Lab of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 200029, China – sequence: 3 givenname: Yu-Hua surname: Li fullname: Li, Yu-Hua organization: Key Lab of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 200029, China – sequence: 4 givenname: Yang surname: Dai fullname: Dai, Yang organization: Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China – sequence: 5 givenname: Yin-Chang surname: Zhu fullname: Zhu, Yin-Chang organization: Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China – sequence: 6 givenname: Jiang surname: Zheng fullname: Zheng, Jiang organization: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China – sequence: 7 givenname: Zhen-Qing surname: Feng fullname: Feng, Zhen-Qing email: fengzhengqing@njmu.edu.cn, fzhenqing@163.com organization: Key Lab of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 200029, China – sequence: 8 givenname: Xiao-Hong surname: Guan fullname: Guan, Xiao-Hong email: xhguan@163.com organization: Key Lab of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 200029, China |
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| Keywords | Therapeutic efficacy Schistosomiasis Chimeric Fab Anti-idiotypic antibody Infection Treatment Antibody Trematode disease Tropical medicine Parasitosis Helminthiasis |
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| Snippet | ► A human–mouse chimeric Fab of monoclonal anti-idiotypic antibody NP30 (chFab-NP30) against Schistosoma japonicum was constructed and expressed in E. coli. ►... The murine monoclonal anti-idiotypic antibody NP30 is a promising therapeutic antibody against Schistosoma japonicum. However, the immunogenicity of murine... |
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| SubjectTerms | Animals Anthelmintics - administration & dosage Anthelmintics - isolation & purification Anti-idiotypic antibody Antibodies, Anti-Idiotypic - administration & dosage Antibodies, Anti-Idiotypic - genetics Antibodies, Anti-Idiotypic - isolation & purification Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - genetics Antibodies, Monoclonal - isolation & purification Biological and medical sciences Chimeric Fab chimerism Diseases caused by trematodes eggs General aspects Helminthic diseases humans immune response Infectious diseases Medical sciences Mice Mice, Inbred BALB C Parasite Egg Count Parasitic diseases Portal Vein - parasitology Recombinant Proteins - administration & dosage Recombinant Proteins - genetics Recombinant Proteins - isolation & purification Schistosoma japonicum Schistosoma japonicum - drug effects Schistosomiases Schistosomiasis Schistosomiasis japonica - drug therapy Schistosomiasis japonica - parasitology survival rate Therapeutic efficacy |
| Title | Expression, characterization and therapeutic efficacy of chimeric Fab of anti-idiotypic antibody NP30 against Schistosoma japonicum |
| URI | https://dx.doi.org/10.1016/j.actatropica.2011.01.006 https://www.ncbi.nlm.nih.gov/pubmed/21376700 https://search.proquest.com/docview/864780066 https://search.proquest.com/docview/902340147 |
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