Inflammasome: A Double-Edged Sword in Liver Diseases

Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interle...

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Published inFrontiers in immunology Vol. 9; p. 2201
Main Authors Luan, Jingyun, Ju, Dianwen
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 25.09.2018
Subjects
adaptive immune
Immunology
inflammasome
innate immune
liver
metabolism
pyroptosis
adaptive immune
innate immune
pyroptosis
metabolism
liver
inflammasome
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Summary:Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-γ (IFN-γ)-dependent responses to prevent the development of liver diseases. However, considerable attention has been attracted to the pathogenic role of inflammasomes in various acute and chronic liver diseases, including viral hepatitis, nanoparticle-induced liver injury, alcoholic and non-alcoholic steatohepatitis. In this review, we summarize the latest advances on the physiological and pathological roles of inflammasomes for further development of inflammasome-based therapeutic strategies for human liver diseases.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: John R. Lukens, University of Virginia, United States; Behdad Afzali, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), United States
Edited by: Rongbin Zhou, University of Science and Technology of China, China
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.02201