possible role of soluble fibrin monomer complex after gastroenterological surgery

• Published in: World journal of gastroenterology : WJG Vol. 23; no. 12; pp. 2209 - 2216
• Main Authors: Kochi, Masatoshi, Shimomura, Manabu, Hinoi, Takao, Egi, Hiroyuki, Tanabe, Kazuaki, Ishizaki, Yasuyo, Adachi, Tomohiro, Tashiro, Hirotaka, Ohdan, Hideki
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.03.2017
• Subjects: Adult; Aged; Aged, 80 and over; Anticoagulants - therapeutic use; Area Under Curve; Blood Coagulation; Digestive System Surgical Procedures; Female; Fibrin - chemistry; Fibrin Fibrinogen Degradation Products - chemistry; Gastroenterology; Humans; Male; Middle Aged; Multivariate Analysis; Postoperative Period; Retrospective Studies; Retrospective Study; Risk Factors; Sensitivity and Specificity; Treatment Outcome; Venous Thromboembolism - etiology; Soluble fibrin monomer complex; Hypercoagulable state; Gastroenterological surgery; Anticoagulant therapy; Venous thromboembolism
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v23.i12.2209

To examine the role of soluble fibrin monomer complex (SFMC) in the prediction of hypercoagulable state after gastroenterological surgery. We collected data on the clinical risk factors and fibrin-related makers from patients who underwent gastroenterological surgery at Hiroshima University Hospital between April 1, 2014 and March 31, 2015. We investigated the clinical significance of SFMC, which is known to reflect the early plasmatic activation of coagulation, in the view of these fibrin related markers. A total of 123 patients were included in the present study. There were no patients with symptomatic VTE. Thirty-five (28%) patients received postoperative anticoagulant therapy. In the multivariate analysis, a high SFMC level on POD 1 was independently associated with D-dimer elevation on POD 7 (OR = 4.31, 95%CI: 1.10-18.30, = 0.03). The cutoff SFMC level was 3.8 μg/mL (AUC = 0.78, sensitivity, 63%, specificity, 89%). The D-dimer level on POD 7 was significantly reduced in high-SFMC patients who received anticoagulant therapy in comparison to high-SFMC patients who did not. The SFMC on POD 1 strongly predicted the hypercoagulable state after gastroenterological surgery than the clinical risk factors and the other fibrin related markers.