New Comprehensive Reference Values for Arterial Vascular Parameters in Children

• Published in: Journal of the American Society of Echocardiography Vol. 33; no. 8; pp. 1014 - 1022.e4
• Main Authors: Torigoe, Tsukasa, Dallaire, Frédéric, Slorach, Cameron, Cardinal, Mikhail-Paul, Hui, Wei, Bradley, Timothy J., Sarkola, Taisto, Mertens, Luc, Jaeggi, Edgar
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020
• Subjects: Arterial stiffness; Cardiovascular; Children; Endothelial function; Intima-media thickness; Normal data; dD; sBP; Arterial stiffness; Intima-media thickness; crPWV; Endothelial function; BP; cfPWV; PWV; sD; CPWV; dBP; Normal data; Children; BMI; Pulse-wave velocity between the right carotid and radial arteries; Body mass index; Pulse-wave velocity between the right carotid and femoral arteries; Pulse-wave velocity; Blood pressure; Systolic ascending aortic diameter; Systolic blood pressure; Central pulse-wave velocity; Diastolic blood pressure; Diastolic ascending aortic diameter
• ISSN: 0894-7317; 1097-6795; 1097-6795
• DOI: 10.1016/j.echo.2020.03.001

Noninvasive measurements of vascular parameters can be used for the detection and risk stratification of cardiovascular diseases. Most vascular parameters are influenced by age and body size, but pediatric reference values are scarce and limited to a few parameters. The aim of this study was to develop pediatric reference values and Z score equations for a comprehensive set of vascular parameters. A total of 292 healthy subjects aged 0 to 18 years were prospectively recruited. Stiffness index β, pressure-strain elastic modulus, common carotid intima-media thickness, brachial flow-mediated dilation, radial augmentation index, central and right arm peripheral artery pulse-wave velocities, and pulse-wave velocity ratio were assessed. Normalization for age and anthropometric variables was performed using parametric multivariate regression modeling. Z scores were assessed for heteroscedasticity, residual association with age and body size, and distribution. Multivariate regression models with various combinations of height, weight, and age were used to obtain Z scores that were independent of age and body size. There was no residual association between Z scores and body size, age, or body mass index. There was no significant departure from the normal distribution. The authors present reference values and Z score equations for a comprehensive set of vascular parameters during childhood. Further studies are necessary to assess their usefulness in detecting the vascular signs of subclinical atherosclerosis and chronic diseases, including congenital heart disease. •Arterial vascular parameters may help detect early cardiovascular diseases.•Current pediatric reference values are scarce and limited to few vascular parameters.•The authors present pediatric reference values for a full set of vascular parameters.•Expressed as Z scores, vascular parameters can be used for all ages and body sizes.