Protective Role of L-3- n -Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy
Epilepsy is a common neurological disease with recurrent seizures and neurobehavioral comorbidities, including cognitive impairment and psychiatric disorders. Recent studies suggest that L-3- -butylphthalide (NBP), an extract from the seeds of Linn. (Chinese celery), ameliorates cognitive dysfunctio...
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Published in | Frontiers in pharmacology Vol. 9; p. 734 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
11.07.2018
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Subjects | |
Online Access | Get full text |
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Summary: | Epilepsy is a common neurological disease with recurrent seizures and neurobehavioral comorbidities, including cognitive impairment and psychiatric disorders. Recent studies suggest that L-3-
-butylphthalide (NBP), an extract from the seeds of
Linn. (Chinese celery), ameliorates cognitive dysfunction in ischemia and/or Alzheimer's disease animal models. However, little is known about the role of NBP in epilepsy and the associated comorbidities. Here, using a pilocarpine-induced chronic epileptic mouse model, we found that NBP supplement not only alleviated seizure severity and abnormal electroencephalogram, but also rescued cognitive and emotional impairments in these epileptic mice. The possible underlying mechanisms may be associated with the protective role of NBP in reducing neuronal loss and in restoring the expression of neural synaptic proteins such as postsynaptic density protein 95 (PSD95) and glutamic acid decarboxylase 65/67 (GAD65/67). In addition, NBP treatment increased the transcription of neuroprotective factors, brain-derived neurotrophic factor and Klotho. These findings suggest that NBP treatment may be a potential strategy for ameliorating epileptogenesis and the comorbidities of cognitive and psychological impairments. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Zhouguang Wang, Wenzhou Medical University, China; Wladyslaw Lason, Institute of Pharmacology PAS, Poland These authors have contributed equally to this work. This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Edited by: Jafri Malin Abdullah, University of Science, Malaysia |
ISSN: | 1663-9812 1663-9812 |
DOI: | 10.3389/fphar.2018.00734 |