Small Ubiquitin-Like Modifier 4 (SUMO4) Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis Including 6,823 Subjects

• Published in: Frontiers in endocrinology (Lausanne) Vol. 8; p. 303
• Main Authors: Li, Yan-yan, Wang, Hui, Yang, Xin-xing, Geng, Hong-yu, Gong, Ge, Kim, Hyun Jun, Zhou, Yan-hong, Wu, Jing-jing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.11.2017
• Subjects: Endocrinology; meta-analysis; polymorphism; rs237025; small ubiquitin-like modifier 4; type 2 diabetes mellitus; meta-analysis; type 2 diabetes mellitus; small ubiquitin-like modifier 4; polymorphism; rs237025
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2017.00303

Many studies suggest that the M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. A meta-analysis consisting of 6,823 subjects from 10 studies was conducted to elucidate relationship between the M55V gene polymorphism and T2DM. Depending on the heterogeneity of the data, either a fixed or random-effects model would be used to assess the combined odds ratio (ORs) and their corresponding 95% confidence interval (CI). gene M55V polymorphism was significantly associated with T2DM in the whole population under allelic (OR: 1.18, 95% CI: 1.10-1.28,  = 1.63 × 10 ), recessive (OR: 1.59, 95% CI: 1.14-2.23,  = 0.006), dominant (OR: 0.815, 95% CI: 0.737-0.901,  = 6.89 × 10 ), homozygous (OR: 1.415, 95% CI: 1.170-1.710,  = 0.0003), heterozygous (OR: 1.191, 95% CI: 1.072-1.323,  = 0.001), and additive genetic models (OR: 1.184, 95% CI: 1.097-1.279,  = 1.63 × 10 ). In our subgroup analysis, a significant association was found again in the Chinese population, but not in Japanese or Iranian population. gene M55V polymorphism may correlate with increased T2DM risk. Chinese carriers of the V allele of the gene M55V polymorphism may be predisposed to developing T2DM.