Wnt Signaling: Pathogen Incursion and Immune Defense

Wnt ligands interact with the transmembrane cell surface receptors Frizzled and ROR/RYK to initiate complex signaling cascades that are crucial for cell physiology and the proper functioning of the immune system. Wnt signaling is instrumental in maintaining immune surveillance and during infections...

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Bibliographic Details
Published inFrontiers in immunology Vol. 10; p. 2551
Main Authors Jati, Suborno, Sarraf, Tresa Rani, Naskar, Debdut, Sen, Malini
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.10.2019
Subjects
actin
cytoskeleton
frizzled
Immunology
microbiota
pathogen
Wnt
microbiota
actin
cytoskeleton
frizzled
macrophage
pathogen
immunity
Wnt
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Summary:Wnt ligands interact with the transmembrane cell surface receptors Frizzled and ROR/RYK to initiate complex signaling cascades that are crucial for cell physiology and the proper functioning of the immune system. Wnt signaling is instrumental in maintaining immune surveillance and during infections by pathogenic microbes helps mount host resistance to infection. Some pathogens, however, utilize Wnt signaling to build a niche for their survival. The goal of this review is to summarize current and developing concepts about the tug of war between Wnt signaling and pathogens for deployment of host resources, focusing mostly on macrophages and cytoskeletal actin dynamics. An additional objective is to outline the interrelation between Wnt signaling and the host microbiota, which is vital for immune defense, discussing in the same perspective, how Wnt signaling could be differentiating pathogen from non-pathogen.
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Reviewed by: Jere W. McBride, University of Texas Medical Branch at Galveston, United States; Elsa Anes, University of Lisbon, Portugal; Laurel L. Lenz, School of Medicine, University of Colorado Denver, United States
Edited by: Ian Marriott, University of North Carolina at Charlotte, United States
This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.02551