Sex-Specific Metabolic Impairments in a Mouse Model of Disrupted Selenium Utilization
The essential micronutrient selenium (Se) provides antioxidant defense and supports numerous biological functions. Obtained through dietary intake, Se is incorporated into selenoproteins the amino acid, selenocysteine (Sec). Mice with genetic deletion of the Se carrier, selenoprotein P (SELENOP), an...
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Published in | Frontiers in nutrition (Lausanne) Vol. 8; p. 682700 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
10.05.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The essential micronutrient selenium (Se) provides antioxidant defense and supports numerous biological functions. Obtained through dietary intake, Se is incorporated into selenoproteins
the amino acid, selenocysteine (Sec). Mice with genetic deletion of the Se carrier, selenoprotein P (SELENOP), and the Se recycling enzyme selenocysteine lyase (SCLY), suffer from sexually dimorphic neurological deficits and require Se supplementation for viability. These impairments are more pronounced in males and are exacerbated by dietary Se restriction. We report here that, by 10 weeks of age, female
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double knockout (DKO) mice supplemented with 1 mg/ml sodium selenite in drinking water develop signs of hyper-adiposity not seen in male DKO mice. Unexpectedly, this metabolic phenotype can be reversed by removing Se from the drinking water at post-natal day 22, just prior to puberty. Restricting access to Se at this age prevents excess body weight gain and restriction from either post-natal day 22 or 37 reduces gonadal fat deposits. These results provide new insight into the sex-dependent relationship between Se and metabolic homeostasis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Nutrition and Metabolism, a section of the journal Frontiers in Nutrition These authors have contributed equally to this work and share first authorship Reviewed by: Paul Copeland, Rutgers Biomedical and Health Sciences, United States; Nikolay Solovyev, Institute of Technology, Sligo, Ireland Edited by: Cristiane Cominetti, Universidade Federal de Goiás, Brazil |
ISSN: | 2296-861X 2296-861X |
DOI: | 10.3389/fnut.2021.682700 |