Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules

As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of cancers, especially those highly aggressive and d...

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Published inFrontiers in pharmacology Vol. 9; p. 1453
Main Authors Chen, Yiming, Jia, Yuping, Song, Weiguo, Zhang, Lei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.12.2018
Subjects
antitumor
drug discovery
hybrids
nitrogen mustard
Pharmacology
side effects
side effects
nitrogen mustard
hybrids
drug discovery
antitumor
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Summary:As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of cancers, especially those highly aggressive and drug-resistant ones. Nitrogen mustard has been widely used as an anticancer drug since the discovery of its antitumor effect in the 1942. However, the lack of selectivity to cancer cells restricts the wide usage of a mass of nitrogen mustard agents to achieve further clinical significance. Discovery of antitumor hybrids using nitrogen mustards as key functional groups has exhibited enormous potential in the drug development. Introduction of nitrogen mustards resulted in improvement in the activity, selectivity, targetability, safety, pharmacokinetics and pharmacodynamics properties of corresponding lead compounds or agents. Herein, the recently developed nitrogen mustard based hybrids have been introduced in the cancer therapy.
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These authors have contributed equally to this work
Edited by: Zhe-Sheng Chen, St. John’s University, United States
Reviewed by: Xiaozhuo Liu, University at Buffalo, United States; Guannan Zhang, University of Pennsylvania, United States
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2018.01453