Classification of individuals with dyslipidaemia controlled by statins according to plasma biomarkers of oxidative stress using cluster analysis
Oxidative stress is a physiological condition that is associated with atherosclerosis, and it can be influenced by diet. Our objective was to group fifty-seven individuals with dyslipidaemia controlled by statins according to four oxidative biomarkers, and to evaluate the diet pattern and blood bioc...
Saved in:
Published in | British journal of nutrition Vol. 103; no. 2; pp. 256 - 265 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge, UK
Cambridge University Press
28.01.2010
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Oxidative stress is a physiological condition that is associated with atherosclerosis, and it can be influenced by diet. Our objective was to group fifty-seven individuals with dyslipidaemia controlled by statins according to four oxidative biomarkers, and to evaluate the diet pattern and blood biochemistry differences between these groups. Blood samples were collected and the following parameters were evaluated: diet intake; plasma fatty acids; lipoprotein concentration; glucose; oxidised LDL (oxLDL); malondialdehyde (MDA); total antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing ability power assays. Individuals were separated into five groups by cluster analysis. All groups showed a difference with respect to at least one of the four oxidative stress biomarkers. The separation of individuals in the first axis was based upon their total antioxidant activity. Clusters located on the right side showed higher total antioxidant activity, higher myristic fatty acid and lower arachidonic fatty acid proportions than clusters located on the left side. A negative correlation was observed between DPPH and the peroxidability index. The second axis showed differences in oxidation status as measured by MDA and oxLDL concentrations. Clusters located on the upper side showed higher oxidative status and lower HDL cholesterol concentration than clusters located on the lower side. There were no differences in diet among the five clusters. Therefore, fatty acid synthesis and HDL cholesterol concentration seem to exert a more significant effect on the oxidative conditions of the individuals with dyslipidaemia controlled by statins than does their food intake. |
---|---|
Bibliography: | http://dx.doi.org/10.1017/S0007114509991711 PII:S0007114509991711 ark:/67375/6GQ-5N95DCBL-G ArticleID:99171 Abbreviations: DPPH, 2,2-diphenyl-1-picrylhydrazyl; FRAP, ferric reducing ability power; MDA, malondialdehyde; oxLDL, oxidised LDL; PC, principal component istex:EB57E2089D3658E365BB4C2511CDFE00CE7D1E68 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-1145 1475-2662 |
DOI: | 10.1017/S0007114509991711 |