Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops ( Humulus lupulus L.)

It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from ho...

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Published inFrontiers in pharmacology Vol. 9; p. 530
Main Authors Jiang, Chuan-Hao, Sun, Tao-Li, Xiang, Da-Xiong, Wei, Shan-Shan, Li, Wen-Qun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 22.05.2018
Subjects
anticancer
hops
molecular mechanism
Pharmacology
phytochemical
xanthohumol
molecular mechanism
hops
xanthohumol
anticancer
phytochemical
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Summary:It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from hops ( L.), with a concentration up to 0.96 mg/L in beer. This review aims to summarize the existing studies focusing on the anticancer activity of Xn and its effects on key signaling molecules. Furthermore, the limitations of current studies and challenges for the clinical use of Xn are discussed.
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This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Reviewed by: Andrzej Stepulak, Medical University of Lublin, Poland; Paula Branquinho Andrade, Universidade do Porto, Portugal; Agnieszka Barbara Najda, University of Life Sciences in Lublin, Poland; Lyndy Joy McGaw, University of Pretoria, South Africa
Edited by: Luc Pieters, University of Antwerp, Belgium
These authors have contributed equally to this work.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2018.00530