Novel strategies to eliminate persistent viral infections

Infection with viruses that have the capacity to modulate or evade the immune response can result in persistence, which can lead to a variety of chronic problems including neoplasia, immunosuppression, autoimmune-like syndromes, and selective organ failure. Recently, two promising new treatment appr...

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Bibliographic Details
Published inTrends in immunology Vol. 29; no. 3; pp. 116 - 124
Main Authors Martinic, Marianne M, von Herrath, Matthias G
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2008
Elsevier Limited
Subjects
Allergy and Immunology
Animals
Antiviral Agents - therapeutic use
Chronic Disease
HIV
Human immunodeficiency virus
Humans
Immune system
Infections
Interleukin-10 - antagonists & inhibitors
T cell receptors
Viral infections
Virus Diseases - drug therapy
Virus Diseases - immunology
Virus Diseases - metabolism
Virus Diseases - prevention & control
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Summary:Infection with viruses that have the capacity to modulate or evade the immune response can result in persistence, which can lead to a variety of chronic problems including neoplasia, immunosuppression, autoimmune-like syndromes, and selective organ failure. Recently, two promising new treatment approaches that target either the inhibitory receptor programmed cell death 1 (PD-1) or neutralize interleukin-10 (IL-10) during chronic viral infection have been described. We discuss how future combination therapies can be used to inhibit viral synthesis as well as strengthen the antiviral response without increasing immunopathology or the development of autoimmune disease.
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ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2007.12.002