Oropharyngeal Candidosis in HIV-Infected Patients-An Update

Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. is the main pathogen, but other species have been isolated. OPC usually presents months or years before other severe opportunistic infections and may...

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Published inFrontiers in microbiology Vol. 9; p. 980
Main Authors Patil, Shankargouda, Majumdar, Barnali, Sarode, Sachin C, Sarode, Gargi S, Awan, Kamran H
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.05.2018
Subjects
AIDS
antifungals
Candida
HIV
Microbiology
opportunistic infections
Oropharyngeal candidosis
Oropharyngeal candidosis
opportunistic infections
AIDS
antifungals
HIV
Candida
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Summary:Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. is the main pathogen, but other species have been isolated. OPC usually presents months or years before other severe opportunistic infections and may indicate the presence or progression of HIV disease. The concept of OPC as a biofilm infection has changed our understanding of its pathobiology. Various anti-fungal agents (both topical and systemic) are available to treat OPC. However, anti-fungal resistance as a result of the long-term use of anti-fungal agents and recurrent oropharyngeal infection in AIDS patients require alternative anti-fungal therapies. In addition, both identifying the causative species and conducting anti-fungal vulnerability testing can improve a clinician's ability to prescribe effective anti-fungal agents. The present review focuses on the current findings and therapeutic challenges for HIV-infected patients with OPC.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Reviewed by: Ruwan Duminda Jayasinghe, University of Peradeniya, Sri Lanka; Peng Li, Peking University, China
Edited by: Chaminda Jayampath Seneviratne, National University of Singapore, Singapore
This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2018.00980