Macropinocytosis: New Insights Into Its Underappreciated Role in Innate Immune Cell Surveillance

Macropinocytosis has received increasing attention in recent years for its various roles in nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases macropinocytosis is initiated by the sudden increase in an external stimulus such as a growth factor. This "indu...

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Bibliographic Details
Published inFrontiers in immunology Vol. 9; p. 2286
Main Author Canton, Johnathan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.10.2018
Subjects
antigen presentation
Immunology
macrophages
macropinocytosis
macropinosome
pattern recognition receptors (PRRs)
PRRs
macrophages
dendritic cells
macropinocytosis
antigen presentation
PRRs
Nod2 signaling adaptor protein
pattern recognition receptors (PRRs)
macropinosome
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Summary:Macropinocytosis has received increasing attention in recent years for its various roles in nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases macropinocytosis is initiated by the sudden increase in an external stimulus such as a growth factor. This "induced" form of macropinocytosis has been the subject of much of the work addressing its mechanism and function over the years. An alternative, "constitutive" form of macropinocytosis restricted to primary innate immune cells also exists, although its mechanism has remained severely understudied. This mini-review focuses on the very recent advances that have shed new light on the initiation, formation and functional relevance of constitutive macropinocytosis in primary innate immune cells. An emphasis is placed on how this new understanding of constitutive macropinocytosis is helping to define the sentinel function of innate immune cells including polarized macrophages and dendritic cells.
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This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
Edited by: Uday Kishore, Brunel University London, United Kingdom
Reviewed by: Kushagra Bansal, Harvard Medical School, United States; Gudrun Stenbeck, Brunel University London, United Kingdom
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.02286