Hippocampal Resting State Functional Connectivity in Patients With Schizophrenia and Unaffected Family Members
The hippocampus is an important candidate region in the study of functional connectivity alterations in schizophrenia (SZ) given its role as a functional hub for multiple brain networks. Although studies have implicated the hippocampus in SZ, no studies have compared hippocampal functional connectiv...
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Published in | Frontiers in psychiatry Vol. 11; p. 278 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
04.05.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The hippocampus is an important candidate region in the study of functional connectivity alterations in schizophrenia (SZ) given its role as a functional hub for multiple brain networks. Although studies have implicated the hippocampus in SZ, no studies have compared hippocampal functional connectivity in healthy participants, patients with SZ, and unaffected family members (UAFMs). Patients and UAFM likely share biomarkers associated with susceptibility to SZ; the study of UAFM may also reveal compensatory markers. Patients with SZ, UAFM, and healthy control (HC) participants underwent resting state magnetic resonance imagingty and completed the Wisconsin Card Sort Task (WCST) as a measure of general cognitive function. We compared functional coupling with a hippocampus seed across the three groups. SZ and UAFM groups shared reductions in connectivity between the hippocampus and the striatum relative to HC. We also identified a significant positive correlation between WCST errors and hippocampal-striatal connectivity in the UAFM group. Hippocampal-striatal rsFC may be associated with familial susceptibility to SZ and with subtle cognitive deficits in the UAFM of individuals with SZ. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Panteleimon Giannakopoulos, Université de Genève, Switzerland This article was submitted to Neuroimaging and Stimulation, a section of the journal Frontiers in Psychiatry These authors have contributed equally to this work Reviewed by: Hao He, Mind Research Network (MRN), United States; Dimitri Van De Ville, Federal Institute of Technology in Lausanne, Switzerland |
ISSN: | 1664-0640 1664-0640 |
DOI: | 10.3389/fpsyt.2020.00278 |