Simulation of Respiratory Mechanics

The dynamic relationship between respiratory muscle effort and the consequent changes in lung volume is investigated. A mathematical simulation based on the structures that form the connection between these two variables makes it possible to lump the contribution from all respiratory muscles into a...

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Bibliographic Details
Published inBiophysical journal Vol. 6; no. 6; pp. 773 - 785
Main Authors Jodat, Ronald W., Horgan, James D., Lange, Ramon L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.1966
Subjects
Biophysical Phenomena
Biophysics
Lung - physiology
Models, Theoretical
Respiration - physiology
Respiratory Physiological Phenomena
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Summary:The dynamic relationship between respiratory muscle effort and the consequent changes in lung volume is investigated. A mathematical simulation based on the structures that form the connection between these two variables makes it possible to lump the contribution from all respiratory muscles into a single time-varying driving force. When this force is applied to the system model, the appropriate lung volume pattern results. The simulation results indicate the accuracy of the model and the validity of the lumped muscle force assumption. In addition, the system model adequately describes abnormal conditions such as decreased lung compliance and increased airway resistance. The results of this simulation suggest that the modeling technique is extremely useful in describing and analyzing complex respiratory system interactions.
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ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(66)86694-8