High-Dose Intravenous Immunoglobulins in the Treatment of Severe Acute Viral Pneumonia: The Known Mechanisms and Clinical Effects

• Published in: Frontiers in immunology Vol. 11; p. 1660
• Main Authors: Liu, Xiaosheng, Cao, Wei, Li, Taisheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.07.2020
• Subjects: Adult; Animals; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - therapeutic use; Antibody-Dependent Enhancement; Betacoronavirus - immunology; Child; Coronavirus Infections - drug therapy; Coronavirus Infections - immunology; Coronavirus Infections - virology; COVID-19; Cytokines - metabolism; Humans; Immunoglobulin Fab Fragments - metabolism; Immunoglobulin Fc Fragments - metabolism; Immunoglobulin G - administration & dosage; Immunoglobulin G - therapeutic use; Immunoglobulins, Intravenous - administration & dosage; Immunoglobulins, Intravenous - therapeutic use; Immunologic Factors - administration & dosage; Immunologic Factors - therapeutic use; Immunology; intravenous immunoglobulin; mechanism of action; Pandemics; Pneumonia, Viral - drug therapy; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; SARS-CoV-2; therapeutic inference; viral pneumonia; COVID-19; mechanism of action; SARS-CoV-2; therapeutic inference; intravenous immunoglobulin; viral pneumonia
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2020.01660

The current outbreak of viral pneumonia, caused by novel coronavirus SARS-CoV-2, is the focus of worldwide attention. The WHO declared the COVID-19 outbreak a pandemic event on Mar 12, 2020, and the number of confirmed cases is still on the rise worldwide. While most infected individuals only experience mild symptoms or may even be asymptomatic, some patients rapidly progress to severe acute respiratory failure with substantial mortality, making it imperative to develop an efficient treatment for severe SARS-CoV-2 pneumonia alongside supportive care. So far, the optimal treatment strategy for severe COVID-19 remains unknown. Intravenous immunoglobulin (IVIg) is a blood product pooled from healthy donors with high concentrations of immunoglobulin G (IgG) and has been used in patients with autoimmune and inflammatory diseases for more than 30 years. In this review, we aim to highlight the known mechanisms of immunomodulatory effects of high-dose IVIg therapy, the immunopathological hypothesis of viral pneumonia, and the clinical evidence of IVIg therapy in viral pneumonia. We then make cautious therapeutic inferences about high-dose IVIg therapy in treating severe COVID-19. These inferences may provide relevant and useful insights in order to aid treatment for COVID-19.