von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke

von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ibα (GPIbα). Over the past decades, it has become clear that many hemostatic factors, including VWF and platelets, a...

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Published inFrontiers in immunology Vol. 10; p. 2884
Main Authors Denorme, Frederik, Vanhoorelbeke, Karen, De Meyer, Simon F
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.12.2019
Subjects
ADAMTS13
Brain Ischemia - immunology
Brain Ischemia - pathology
Brain Ischemia - therapy
Humans
Immunology
Inflammation - immunology
Inflammation - pathology
Inflammation - therapy
ischemic stroke
Platelet Glycoprotein GPIb-IX Complex - immunology
platelet glycoprotein Ibα
Signal Transduction - immunology
Stroke - immunology
Stroke - pathology
Stroke - therapy
thromboinflammation
Thrombosis - immunology
Thrombosis - pathology
Thrombosis - therapy
von Willebrand factor
von Willebrand Factor - immunology
thromboinflammation
ADAMTS13
platelet glycoprotein Ibα
von Willebrand factor
ischemic stroke
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Summary:von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ibα (GPIbα). Over the past decades, it has become clear that many hemostatic factors, including VWF and platelets, are also involved in inflammatory processes, forming intriguing links between hemostasis, thrombosis, and inflammation. The so-called "thrombo-inflammatory" nature of the VWF-platelet axis becomes increasingly recognized in different cardiovascular pathologies, making it a potential therapeutic target to interfere with both thrombosis and inflammation. In this review, we discuss the current evidence for the thrombo-inflammatory activity of VWF with a focus on the VWF-GPIbα axis and discuss its implications in the setting of ischemic stroke.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Thomas Daniel Nightingale, Queen Mary University of London, United Kingdom; Elizabeth Gardiner, Australian National University, Australia
Edited by: Mirta Schattner, National Council for Scientific and Technical Research (CONICET), Argentina
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.02884