Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease

Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneo...

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Bibliographic Details
Published inFrontiers in immunology Vol. 10; p. 346
Main Authors Grieshaber-Bouyer, Ricardo, Nigrovic, Peter A
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.03.2019
Subjects
CD177
granulopoiesis
immune mediated disease
Immunology
neutrophil
neutrophil migration
therapeutic opportunities
neutrophil migration
autoimmune
granulopoiesis
therapeutic targeting
therapeutic opportunities
neutrophil
CD177
immune mediated disease
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Summary:Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Reviewed by: Michael Hickey, Monash University, Australia; James N. Jarvis, University at Buffalo, United States
Edited by: Abbe N. de Vallejo, University of Pittsburgh, United States
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00346