Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders

As an important endogenous gaseous signaling molecule, hydrogen sulfide (H S) exerts various effects in the body. A variety of pathological changes, such as cancer, glycometabolic disorders, and diabetes, are associated with altered endogenous levels of H S, especially decreased. Therefore, the supp...

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Published inFrontiers in pharmacology Vol. 8; p. 664
Main Authors Yang, Chun-Tao, Chen, Li, Xu, Shi, Day, Jacob J, Li, Xiang, Xian, Ming
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.09.2017
Subjects
cancer
donor
glucose metabolism
hydrogen sulfide
Pharmacology
cancer
donor
hydrogen sulfide
glucose metabolism
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Summary:As an important endogenous gaseous signaling molecule, hydrogen sulfide (H S) exerts various effects in the body. A variety of pathological changes, such as cancer, glycometabolic disorders, and diabetes, are associated with altered endogenous levels of H S, especially decreased. Therefore, the supplement of H S is of great significance for the treatment of diseases containing the above pathological changes. At present, many efforts have been made to increase the levels of H S by administration of gaseous H S, simple inorganic sulfide salts, sophisticated synthetic slow-releasing controllable H S donors or materials, and using H S stimulating agents. In this article, we reviewed the recent development of H S releasing/stimulating reagents and their potential applications in two common pathological processes including cancer and glycometabolic disorders.
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Edited by: Junbao Du, Peking University First Hospital, China
Reviewed by: Egidio Iorio, Istituto Superiore di Sanità, Italy; Qiang Zhao, Nankai University, China; YiChun Zhu, Children’s Hospital, Fudan University, China
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2017.00664