Comparison of Computed and Acquired DWI in the Assessment of Rectal Cancer: Image Quality and Preoperative Staging

• Published in: Frontiers in oncology Vol. 12; p. 788731
• Main Authors: Xia, Yihan, Wang, Lan, Wu, Zhiyuan, Tan, Jingwen, Fu, Meng, Fu, Caixia, Pan, Zilai, Zhu, Lan, Yan, Fuhua, Shen, Hailin, Ma, Qianchen, Cai, Gang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.03.2022
• Subjects: computed diffusion images; diagnostic performance; diffusion-weighted imaging; image quality; Oncology; rectal cancer; image quality; diagnostic performance; diffusion-weighted imaging; computed diffusion images; rectal cancer
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2022.788731

The aim of the study was to evaluate the computed diffusion-weighted images (DWI) in image quality and diagnostic performance of rectal cancer by comparing with the acquired DWI. A total of 103 consecutive patients with primary rectal cancer were enrolled in this study. All patients underwent two DWI sequences, namely, conventional acquisition with b = 0 and 1,000 s/mm (aDWI ) and another with b = 0 and 700 s/mm on a 3.0T MR scanner (MAGNETOM Prisma; Siemens Healthcare, Germany). The images (b = 0 and 700 s/mm ) were used to compute the diffusion images with b value of 1,000 s/mm (cDWI ). Qualitative and quantitative analysis of both computed and acquired DWI images was performed, namely, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and signal intensity ratio (SIR), and also diagnostic staging performance. Interclass correlation coefficients, weighted κ coefficient, Friedman test, Wilcoxon paired test, and McNemar or Fisher test were used for repeatability and comparison assessment. Compared with the aDWI images, the cDWI ones exhibited significant higher scores of subjective image quality (all P <0.050). SNR, SIR, and CNR of the cDWI images were superior to those of the aDWI ones (P <0.001). The overall diagnostic accuracy of computed images was higher than that of the aDWI images in T stage (P <0.001), with markedly better sensitivity and specificity in distinguishing T1-2 tumors from the T3-4 ones (P <0.050). cDWI images from lower b values might be a useful alternative option and comparable to the acquired DWI, providing better image quality and diagnostic performance in preoperative rectal cancer staging.