Microbiome, Immunosenescence, and Chronic Kidney Disease

The gut microbiome is known as an important predictive tool for perceiving characteristic shifts in disease states. Multiple renal diseases and pathologies seem to be associated with gut dysbiosis which directly affects host homeostasis. The gastrointestinal-kidney dialogue confers interesting infor...

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Published inFrontiers in medicine Vol. 8; p. 661203
Main Authors Stavropoulou, Elisavet, Kantartzi, Konstantia, Tsigalou, Christina, Aftzoglou, Konstantina, Voidarou, Chrysa, Konstantinidis, Theocharis, Chifiriuc, Mariana Carmen, Thodis, Elias, Bezirtzoglou, Eugenia
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.03.2021
Subjects
ageing
gut
gut-kidney axis
immunosenescence
kidney
Medicine
microbiome
microbiota
kidney
ageing
chronic kidney disease
immunosenescence
gut
microbiome
gut-kidney axis
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Summary:The gut microbiome is known as an important predictive tool for perceiving characteristic shifts in disease states. Multiple renal diseases and pathologies seem to be associated with gut dysbiosis which directly affects host homeostasis. The gastrointestinal-kidney dialogue confers interesting information about the pathogenesis of multiple kidney diseases. Moreover, aging is followed by specific shifts in the human microbiome, and gradual elimination of physiological functions predisposes the microbiome to inflammaging, sarcopenia, and disease. Aging is characterized by a microbiota with an abundance of disease-associated pathobionts. Multiple factors such as the immune system, environment, medication, diet, and genetic endowment are involved in determining the age of the microbiome in health and disease. Our present review promotes recently acquired knowledge and is expected to inspire researchers to advance studies and investigations on the involved pathways of the gut microbiota and kidney axis.
Bibliography:Edited by: Maria J. Stangou, Aristotle University of Thessaloniki, Greece
This article was submitted to Nephrology, a section of the journal Frontiers in Medicine
Reviewed by: Evangelos Papachristou, University of Patras, Greece; Erasmia Sampani, Hippokration General Hospital Thessaloniki Greece, Greece
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.661203