Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential

Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospectin...

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Published inFrontiers in pharmacology Vol. 8; p. 828
Main Authors Agrawal, Shivankar, Acharya, Debabrata, Adholeya, Alok, Barrow, Colin J, Deshmukh, Sunil K
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.11.2017
Subjects
anticancer
antimicrobial
marine natural products
microbe derived-compounds
nonribosomal peptides
Pharmacology
antimicrobial
marine natural products
microbe derived-compounds
nonribosomal peptides
anticancer
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Summary:Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs.
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Reviewed by: Nishikant Wase, University of Nebraska Lincoln, United States; Sonia Emanuele, Università degli Studi di Palermo, Italy
Edited by: Bey Hing Goh, Monash University Malaysia, Malaysia
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2017.00828