Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer

• Published in: Medicina (Kaunas, Lithuania) Vol. 56; no. 2; p. 48
• Main Authors: Lee, Jae-Ho, Bae, An-Na, Jung, And Soo-Jung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 21.01.2020; MDPI AG
• Subjects: cancer prognosis; clinical analysis; colorectal cancer; double-stand breaks; rad51; RAD51; colorectal cancer; double-stand breaks; cancer prognosis; clinical analysis
• ISSN: 1648-9144; 1010-660X; 1648-9144; 1010-660X
• DOI: 10.3390/medicina56020048

RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in colorectal cancer (CRC), and evaluated the clinicopathological and prognostic significance of RAD51. The RAD51 expression was examined in 48 CRCs and paired adjacent non-tumor tissues. We further evaluated the survival to determine the prognostic value of RAD51 in our CRC and The Cancer Genome Atlas (TCGA) data. We confirmed that the RAD51 expression in tumor tissues, compared with that of paired non-tumor tissues, was upregulated 2.5-fold. Additionally, the RAD51 expression was significantly associated with the T stage ( = 0.027). According to a higher T stage, the RAD51 expression showed an increasing trend. However, the RAD51 expression did not show a prognostic value statistically. We confirmed that RAD51 was upregulated in tumors and was significantly associated with the T stage. Although there was no statistically significant prognostic value found in our samples and TGCA data, our study will provide new insight for RAD51 in CRC.