Detection of Nocturnal Slow Wave Sleep Based on Cardiorespiratory Activity in Healthy Adults

• Published in: IEEE journal of biomedical and health informatics Vol. 21; no. 1; pp. 123 - 133
• Main Authors: Xi Long, Fonseca, Pedro, Aarts, Ronald M., Haakma, Reinder, Rolink, Jerome, Leonhardt, Steffen
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.01.2017; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Adult; Adults; Aged; Aged, 80 and over; Cardiorespiratory activity; Consolidation; Delay effects; Electrocardiography; Electrocardiography - methods; Energy conservation; Envelopes; Feature extraction; feature smoothing; Female; Geriatrics; Humans; Male; Middle Aged; Night; Noise measurement; Noise reduction; Older people; Polysomnography - methods; Respiration; Sleep; Sleep - physiology; slow wave sleep detection; Smoothing; Smoothing methods; spline fitting; Splines (mathematics); time delay; Variation; Young Adult
• ISSN: 2168-2194; 2168-2208; 2168-2208
• DOI: 10.1109/JBHI.2015.2487446

Human slow wave sleep (SWS) during bedtime is paramount for energy conservation and memory consolidation. This study aims at automatically detecting SWS from nocturnal sleep using cardiorespiratory signals that can be acquired with unobtrusive sensors in a home-based scenario. From the signals, time-dependent features are extracted for continuous 30-s epochs. To reduce the measuring noise, body motion artifacts, and/or within-subject variability in physiology conveyed by the features, and thus, enhance the detection performance, we propose to smooth the features over each night using a spline fitting method. In addition, it was found that the changes in cardiorespiratory activity precede the transitions between SWS and the other sleep stages (non-SWS). To this matter, a novel scheme is proposed that performs the SWS detection for each epoch using the feature values prior to that epoch. Experiments were conducted with a large dataset of 325 overnight polysomnography (PSG) recordings using a linear discriminant classifier and tenfold cross validation. Features were selected with a correlation-based method. Results show that the performance in classifying SWS and non-SWS can be significantly improved when smoothing the features and using the preceding feature values of 5-min earlier. We achieved a Cohen's Kappa coefficient of 0.57 (at an accuracy of 88.8%) using only six selected features for 257 recordings with a minimum of 30-min overnight SWS that were considered representative of their habitual sleeping pattern at home. These features included the standard deviation, low-frequency spectral power, and detrended fluctuation of heartbeat intervals as well as the variations of respiratory frequency and upper and lower respiratory envelopes. A marked drop in Kappa to 0.21 was observed for the other nights with SWS time of less than 30 min, which were found to more likely occur in elderly. This will be the future challenge in cardiorespiratory-based SWS detection.