Anti-allergic Inflammatory Effects of the Essential Oil From Fruits of Zanthoxylum coreanum Nakai

• Published in: Frontiers in pharmacology Vol. 9; p. 1441
• Main Authors: Guo, Rui Hong, Park, Jung Up, Jo, Se Jin, Ahn, Jae Hun, Park, Jong Hwan, Yang, Ji Yoon, Lee, Sung Suk, Park, Mi Jin, Kim, Young Ran
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.12.2018
• Subjects: COX-2; degranulation; inflammatory mediators; iNOS; NF-κB; Pharmacology; Zanthoxylum coreanum Nakai; Zanthoxylum coreanum Nakai; inflammatory mediators; NF-κB; COX-2; atopic dermatitis; iNOS; degranulation; MAPK
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2018.01441

is a rare shrub which grows in Korea and China. Pericarp of has been used as a crude medicine, but there are few researches about the pharmacologic activities. The present study was designed to investigate the anti-allergic inflammatory activities of the essential oil from fruits of ( ). Our findings showed that inhibited both the IgE-antigen complex or PMA/A23187-induced β-hexosaminidase release and IL-4 production dose-dependently in RBL-2H3 mast cells, and confirmed that at the tested concentrations did not show cytotoxicity to RBL-2H3 cells by MTS assay. Additionally, we found that showed the significant inhibition on LPS-induced overproduction of TNF-α, IL-6 and NO. Consistently, the protein levels of iNOS and COX-2 were also remarkably decreased by treatment. Herein, Our mechanistic studies revealed that significantly suppressed the activation of transcription factor NF-κB in PMA-activated 293T cells, and further inhibited NF-κB p65 translocation into the nucleus in LPS-stimulated RAW264.7 cells. Further investigation identified that down-regulated LPS-induced phosphorylation of MAPK (JNK, ERK, and p38) signal pathway. For incremental research, we established an DNCB-induced atopic dermatitis model in BALB/c mice, and found that remarkably inhibited DNCB-induced ear swelling and AD-like symptoms. Based on these findings, is suggested to have a therapeutic potential for the allergic inflammatory diseases.