Anti-allergic Inflammatory Effects of the Essential Oil From Fruits of Zanthoxylum coreanum Nakai
is a rare shrub which grows in Korea and China. Pericarp of has been used as a crude medicine, but there are few researches about the pharmacologic activities. The present study was designed to investigate the anti-allergic inflammatory activities of the essential oil from fruits of ( ). Our finding...
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Published in | Frontiers in pharmacology Vol. 9; p. 1441 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
12.12.2018
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Subjects | |
Online Access | Get full text |
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Summary: | is a rare shrub which grows in Korea and China. Pericarp of
has been used as a crude medicine, but there are few researches about the pharmacologic activities. The present study was designed to investigate the anti-allergic inflammatory activities of the essential oil from fruits of
(
). Our findings showed that
inhibited both the IgE-antigen complex or PMA/A23187-induced β-hexosaminidase release and IL-4 production dose-dependently in RBL-2H3 mast cells, and confirmed that
at the tested concentrations did not show cytotoxicity to RBL-2H3 cells by MTS assay. Additionally, we found that
showed the significant inhibition on LPS-induced overproduction of TNF-α, IL-6 and NO. Consistently, the protein levels of iNOS and COX-2 were also remarkably decreased by
treatment. Herein, Our mechanistic studies revealed that
significantly suppressed the activation of transcription factor NF-κB in PMA-activated 293T cells, and further inhibited NF-κB p65 translocation into the nucleus in LPS-stimulated RAW264.7 cells. Further investigation identified that
down-regulated LPS-induced phosphorylation of MAPK (JNK, ERK, and p38) signal pathway. For incremental research, we established an DNCB-induced atopic dermatitis model in BALB/c mice, and found that
remarkably inhibited DNCB-induced ear swelling and AD-like symptoms. Based on these findings,
is suggested to have a therapeutic potential for the allergic inflammatory diseases. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Edited by: Cheorl-Ho Kim, Sungkyunkwan University, South Korea Reviewed by: Sung-Kwon Moon, Chung-Ang University, South Korea; William Chi-Shing Tai, Hong Kong Polytechnic University, Hong Kong |
ISSN: | 1663-9812 1663-9812 |
DOI: | 10.3389/fphar.2018.01441 |