Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish

Ectotherms choose the best thermal conditions to mount a successful immune response, a phenomenon known as behavioral fever. The cumulative evidence suggests that behavioral fever impacts positively upon lymphocyte proliferation, inflammatory cytokine expression, and other immune functions. In this...

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Published inFrontiers in immunology Vol. 9; p. 1241
Main Authors Boltana, Sebastian, Aguilar, Andrea, Sanhueza, Nataly, Donoso, Andrea, Mercado, Luis, Imarai, Monica, Mackenzie, Simon
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.06.2018
Subjects
Animals
Behavior, Animal
behavioral fever
Body Temperature Regulation
Computational Biology - methods
cytokine release
Cytokines - metabolism
Epigenesis, Genetic
epigenetic modification
Fishes - physiology
Gene Expression Profiling
gene regulation
Immunity
Immunity, Innate
Immunology
Lymphocyte Activation - immunology
lymphocyte proliferation
Lymphocytes - immunology
Lymphocytes - metabolism
Transcriptome
epigenetic modification
behavioral fever
cytokine release
gene regulation
lymphocyte proliferation
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Summary:Ectotherms choose the best thermal conditions to mount a successful immune response, a phenomenon known as behavioral fever. The cumulative evidence suggests that behavioral fever impacts positively upon lymphocyte proliferation, inflammatory cytokine expression, and other immune functions. In this study, we have explored how thermal choice during infection impacts upon underpinning molecular processes and how temperature increase is coupled to the immune response. Our results show that behavioral fever results in a widespread, plastic imprint on gene regulation, and lymphocyte proliferation. We further explored the possible contribution of histone modification and identified global associations between temperature and histone changes that suggest epigenetic remodeling as a result of behavioral fever. Together, these results highlight the critical importance of thermal choice in mobile ectotherms, particularly in response to an infection, and demonstrate the key role of epigenetic modification to orchestrate the thermocoupling of the immune response during behavioral fever.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Edited by: Lluis Tort, Universidad Autónoma de Barcelona, Spain
Reviewed by: Magdalena Chadzińska, Jagiellonian University, Poland; Elżbieta Żbikowska, Nicolaus Copernicus University in Toruń, Poland
Specialty section: This article was submitted to Comparative Immunology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.01241