SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer

• Published in: Oncotarget Vol. 6; no. 35; pp. 37750 - 37757
• Main Authors: Tian, Jing, Liu, Yaping, Zhu, Beibei, Tian, Yao, Zhong, Rong, Chen, Wei, Lu, Xinghua, Zou, Li, Shen, Na, Qian, Jiaming, Li, Hui, Miao, Xiaoping, Wang, Li
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 10.11.2015
• Subjects: Alleles; Case-Control Studies; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Polymorphism, Single Nucleotide - genetics; Prognosis; Real-Time Polymerase Chain Reaction; Research Paper; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoprotein, U2 Small Nuclear - genetics; Risk Factors; RNA Splicing - genetics; RNA Splicing Factors; RNA, Messenger - genetics; Smoking - adverse effects; Spliceosomes - genetics; genetic variants; pancreatic cancer; drinking; smoking; RNA splicing
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.5647

A two-stage case-control study was conducted to examine the association between six candidate U2-depedent spliceosome genes (SRSF1, SRSF2, SF3A1, SF3B1, SF1 and PRPF40B) and pancreatic cancer (PC). Subjects with one or two T alleles at rs2074733 in SF3A1 had a lower risk of PC compared to those with two C alleles in combined two populations (OR: 0.59, 95% confidence interval: 0.48-0.73, False discovery rate (FDR)-P = 1.5E-05). Moreover, the presence of the higher-risk genotype at rs2074733 plus smoking or drinking had synergic effects on PC risk. These findings illustrate that RNA splicing-related genes appear to be associated with the occurrence of PC, and show synergic interactions with smoking and drinking in the additive model. In the future, our novel findings should be further confirmed by functional studies and independent large-scale population studies.