EPCR Gene Ser219Gly Polymorphism and Venous Thromboembolism: A Meta-Analysis of 9,494 Subjects

Although gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidate the potential relationship between the gene Ser219Gly pol...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in physiology Vol. 8; p. 339
Main Authors Li, Yan-yan, Wu, Jing-jing, Yang, Xin-xing, Geng, Hong-yu, Gong, Ge, Kim, Hyun Jun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.05.2017
Subjects
EPCR
genetic
Physiology
polymorphism
Ser219Gly
venous thromboembolism
genetic
EPCR
polymorphism
Ser219Gly
venous thromboembolism
Online AccessGet full text
ISSN1664-042X
1664-042X
DOI10.3389/fphys.2017.00339

Cover

More Information
Summary:Although gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidate the potential relationship between the gene Ser219Gly polymorphism and VTE. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed or random effect models. The current meta-analysis suggested that there was a significant association between gene Ser219Gly polymorphism and VTE under allelic (OR: 1.42, 95% CI: 1.21-1.66, = 1.30 × 10 ), recessive (OR: 2.02, 95% CI: 1.44-2.85, = 5.35 × 10 ), homozygous (OR: 2.24, 95% CI: 1.59-3.16, = 3.66 × 10 ), and additive genetic models (OR: 1.63, 95% CI: 1.30-2.04, = 2.24 × 10 ). gene Ser219Gly polymorphism was associated with an elevated risk of VTE and the Gly residue carriers of the gene might be predisposed to VTE.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by: John D. Imig, Medical College of Wisconsin, United States
This article was submitted to Vascular Physiology, a section of the journal Frontiers in Physiology
Reviewed by: Martin Franz Reiner, Cantonal Hospital Baden, Switzerland; Minoli Perera, Northwestern University, United States
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2017.00339