Metalloporphyrins – An Update

Metalloporphyrins are structural analogs of heme and their potential use in the management of neonatal hyperbilirubinemia has been the subject of considerable research for more than three decades. The pharmacological basis for using this class of compounds to control bilirubin levels is the targeted...

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Published inFrontiers in pharmacology Vol. 3; p. 68
Main Authors Schulz, Stephanie, Wong, Ronald J., Vreman, Hendrik J., Stevenson, David K.
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 01.01.2012
Frontiers Media S.A
Subjects
Bilirubin
heme oxygenase
Hemolysis
Jaundice
Neonatal Hyperbilirubinemia
Pharmacology
heme oxygenase
bilirubin
hemolysis
neonatal hyperbilirubinemia
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Summary:Metalloporphyrins are structural analogs of heme and their potential use in the management of neonatal hyperbilirubinemia has been the subject of considerable research for more than three decades. The pharmacological basis for using this class of compounds to control bilirubin levels is the targeted blockade of bilirubin production through the competitive inhibition of heme oxygenase (HO), the rate-limiting enzyme in the bilirubin production pathway. Ongoing research continues in the pursuit of identifying ideal metalloporphyrins, which are safe and effective, by defining therapeutic windows and targeted interventions for the treatment of excessive neonatal hyperbilirubinemia.
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Reviewed by: Thor Willy Ruud Hansen, Oslo University Hospital, Norway; Jon Watchko, University of Pittsburgh School of Medicine, USA
Edited by: Mahin D. Maines, University of Rochester School of Medicine, USA
This article was submitted to Frontiers in Drug Metabolism and Transport, a specialty of Frontiers in Pharmacology.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2012.00068