Association of MHC-I genotypes with disease progression in HIV/SIV infections
Virus-specific cytotoxic T lymphocytes (CTLs) are major effectors in acquired immune responses against viral infection. Virus-specific CTLs recognize specific viral peptides presented by major histocompatibility complex class-I (MHC-I) on the surface of virus-infected target cells via their T cell r...
Saved in:
Published in | Frontiers in microbiology Vol. 3; p. 234 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Research Foundation
01.01.2012
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Virus-specific cytotoxic T lymphocytes (CTLs) are major effectors in acquired immune responses against viral infection. Virus-specific CTLs recognize specific viral peptides presented by major histocompatibility complex class-I (MHC-I) on the surface of virus-infected target cells via their T cell receptor (TCR) and eliminate target cells by both direct and indirect mechanisms. In human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections, host immune responses fail to contain the virus and allow persistent viral replication, leading to AIDS progression. CTL responses exert strong suppressive pressure on HIV/SIV replication and cumulative studies have indicated association of HLA/MHC-I genotypes with rapid or slow AIDS progression. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Hironori Sato, National Institute of Infectious Diseases, Japan This article was submitted to Frontiers in Virology, a specialty of Frontiers in Microbiology. Reviewed by: Takamasa Ueno, Kumamoto University, Japan Hirofumi Akari, Kyoto University, Japan |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2012.00234 |