Apoproteins E, A-I, and SAA in Macrophage Pathobiology Related to Atherogenesis

Macrophages are core cellular elements of both early and advanced atherosclerosis. They take up modified lipoproteins and become lipid-loaded foam cells and secrete factors that influence other cell types in the artery wall involved in atherogenesis. Apoproteins E, AI, and SAA are all found on HDL w...

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Bibliographic Details
Published inFrontiers in pharmacology Vol. 10; p. 536
Main Authors Getz, Godfrey S, Reardon, Catherine A
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.05.2019
Subjects
apoA-I
apoE
cholesterol efflux
macrophage
oxidation
Pharmacology
SAA
atherosclerosis
SAA
apoE
oxidation
macrophage
cholesterol efflux
apoA-I
mimetic peptides
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Summary:Macrophages are core cellular elements of both early and advanced atherosclerosis. They take up modified lipoproteins and become lipid-loaded foam cells and secrete factors that influence other cell types in the artery wall involved in atherogenesis. Apoproteins E, AI, and SAA are all found on HDL which can enter the artery wall. In addition, apoE is synthesized by macrophages. These three apoproteins can promote cholesterol efflux from lipid-loaded macrophages and have other functions that modulate macrophage biology. Mimetic peptides based on the sequence or structure of these apoproteins replicate some of these properties and are potential therapeutic agents for the treatment of atherosclerosis to reduce cardiovascular diseases.
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Edited by: Alfonso Pompella, University of Pisa, Italy
Reviewed by: Szilvia Benkő, University of Debrecen, Hungary; Francesca Vinchi, Universität Heidelberg, Germany
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2019.00536