Phytotrapy of cyclophosphamide-induced immunosuppression

• Published in: Environmental toxicology and pharmacology Vol. 39; no. 3; pp. 1262 - 1275
• Main Authors: Shirani, Kobra, Hassani, Faezeh Vahdati, Razavi-Azarkhiavi, Kamal, Heidari, Somayeh, Zanjani, Bamdad Riahi, Karimi, Gholamreza
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2015
• Subjects: Animals; Cyclophosphamide; Cyclophosphamide - antagonists & inhibitors; Databases, Bibliographic; Emergency; Herbal; Humans; Immunosuppressive Agents - antagonists & inhibitors; Immunotoxicity; Phytotherapy; Plant Extracts - pharmacology; Protect; MLE; Immunotoxicity; IgG; TLC; HT; IgM; LPS; MLP; IFN-γ; RBC; Spp; GM-CSF; SFI; BMC; WBC; Herbal; Hb; LBP; Phytotherapy; ODPs; QHS; NBT; Protect; PFCs; CR3; IP; IL-2; PSM; CP; PWBC; ZYQL; ALDH; CD4; Cyclophosphamide; TNF-α; CD8; DNA; DTH; HA; CTL; DLC; NK; TLRs; complement receptor 3; interleukin-2; bone marrow cells; plaque forming cells; toll-like receptors; granulocyte macrophage colony stimulating factor; Marjoram leaf powder; natural killer; Zhuyeqing Liquor; cyclophosphamide; Marjoram leaf aqueous extract; aldehyde dehydrogenase; haemagglutinating titer; humoral antibody; total leukocyte count; delayed-type hypersensitivity; cluster of differentiation 4; cluster of differentiation 8; lipopolysaccharide; polysaccharides isolated from Makgeolli; cytotoxic T lymphocytes; hemoglobin; quantitative hemolysis of SRBC; red blood cell; interferon-gama; deoxyribonucleic acid; tumor necrosis factor alpha; nitroblue tetrazolium; polysaccharides from O. dillenii; peripheral white blood cell; immunoglobulin G; intraperitoneal; white blood cell; immunoglobulin M; L. barbarum polysaccharides; Shenqi Fuzheng injection; species; differential leukocyte count
• ISSN: 1382-6689; 1872-7077; 1872-7077
• DOI: 10.1016/j.etap.2015.04.012

•Reviews of the effects of plant extracts, active components and their derivatives on immunosuppression of CP are presented.•The various plant-derived compounds affecting the immune system are discussed.•Immunologic effects of CP administration are reviewed. Cyclophosphamide (CP) is a cytotoxic drug that can suppress both humoral and cellular immunity. Combining traditional medicinal herbs and chemotherapy drugs are used to improve immunity and quality of life performance status. In this paper, the effects of plant extracts, active components and their derivatives on immunosuppression of CP are discussed. Appropriate keywords were used to search through PubMed, Google Scholar, and Sciverse. All relevant results published from 1990 to date were chosen for final review. Over 50 references were found in which plant extracts, active components and their derivatives have been tested for their immune protective effects against CP-induced immune toxicity. Although there are several plants shown to be effective in animal models, no study was carried out on human subjects. According to the results; we can claim that plants and their active ingredients are good candidates for alternative adjuvant chemotherapy in reducing the immunotoxicity of CP.