Association Between Cortical Superficial Siderosis and Dementia in Patients With Cognitive Impairment: A Meta-Analysis

• Published in: Frontiers in neurology Vol. 10; p. 8
• Main Authors: Zhou, Chenheng, Liu, Keqin, Yan, Shenqiang, Jin, Ying
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2019
• Subjects: Alzheimer's disease; cognitive impairment; dementia; meta-analysis; Neurology; superficial siderosis; meta-analysis; superficial siderosis; dementia; cognitive impairment; Alzheimer's disease
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2019.00008

It remains unclear whether cortical superficial siderosis (cSS) is associated with dementia and its subtypes. We thus performed a meta-analysis to evaluate the relationship between dementia and cSS. We searched EMBASE, PubMed, and Web of Science for relevant studies assessing risk of dementia and prevalence of cSS in patients with cognitive impairment. Fixed-effects and random-effects models were performed. Seven eligible studies including 3,218 patients with definite cognitive impairment were pooled in meta-analysis. The prevalence of cSS was 3.4%. The pooled analysis demonstrates odds ratio for cSS and dementia to be 1.60 (95% CI 1.04-2.44; = 0.031). Subgroup analysis further indicated a significant association between cSS and Alzheimer's disease (AD) (OR = 2.01, 95% CI 1.34-3.02; < 0.001), but not non-AD dementia (OR = 0.700, 95% CI 0.435-1.128; = 0.143). Our meta-analysis of available published data demonstrates an increased prevalence of dementia in the subjects with pre-existing cSS, especially for AD. These findings suggest cSS to be a candidate imaging indicator for AD. Further longitudinal research is needed to investigate the clinical relevance.