Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients

• Published in: Frontiers in cardiovascular medicine Vol. 8; p. 727745
• Main Authors: Sun, Wei, Shen, Xuehua, Wang, Jing, Zhu, Shuangshuang, Zhang, Yanting, Wu, Chun, Xie, Yuji, Yang, Yun, Dong, Nianguo, Wang, Guohua, Li, Yuman, Lv, Qing, Liang, Bo, Zhang, Li, Xie, Mingxing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.11.2021
• Subjects: cardiovascular magnetic resonance; Cardiovascular Medicine; diffuse myocardial fibrosis; extracellular volume fraction; heart transplant; speckle tracking echocardiography; diffuse myocardial fibrosis; heart transplant; cardiovascular magnetic resonance; extracellular volume fraction; speckle tracking echocardiography
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2021.727745

This study aimed to: (1) evaluate the association between myocardial fibrosis (MF) quantified by extracellular volume fraction (ECV) and myocardial strain measured by two-dimensional (2D)- and three-dimensional speckle-tracking echocardiography (3D-STE) and (2) further investigate which strain parameter measured by 2D- and 3D-STE is the more robust predictor of MF in heart transplant (HT) recipients. A total of 40 patients with HT and 20 healthy controls were prospectively enrolled. Left ventricular (LV)-global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were measured by 2D- and 3D-STE. LV diffuse MF was defined by cardiovascular magnetic resonance (CMR)-ECV. The HT recipients had a significantly higher native T1 and ECV than healthy controls (1043.8 ± 34.0 vs. 999.7 ± 19.7 ms, < 0.001; 26.6 ± 2.7 vs. 24.3 ± 1.8%, = 0.02). The 3D- and 2D-STE-LVGLS and LVGCS were lower ( < 0.005) in the HT recipients than in healthy controls. ECV showed a moderate correlation with 2D-LVGLS ( = 0.53, = 0.002) and 3D-LVGLS ( = 0.60, < 0.001), but it was not correlated with 2D or 3D-LVGCS, or LVGRS. Furthermore, 3D-LVGLS and 2D-LVGLS had a similar correlation with CMR-ECV ( = 0.60 vs. 0.53, = 0.670). A separate stepwise multivariate linear analysis showed that both the 2D-LVGLS (β = 0.39, = 0.019) and 3D-LVGLS (β = 0.54, < 0.001) were independently associated with CMR-ECV. CMR marker of diffuse MF was present in asymptomatic patients with HT and appeared to be associated with decreased myocardial strain by echocardiography. Both the 2D- and 3D-LVGLS were independently correlated with diffuse LVMF, which may provide an alternative non-invasive tool for monitoring the development of adverse fibrotic remodeling during the follow-up of HT recipients.