Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract

• Published in: Human reproduction update Vol. 6; no. 5; pp. 495 - 504
• Main Authors: Fowler, D. J., Nicolaides, K. H., Miell, J. P.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2000; Oxford Publishing Limited (England)
• Subjects: Embryo Implantation - physiology; Embryonic and Fetal Development; Endometrium - physiology; Female; female reproductive tract; Genitalia, Female - physiology; Humans; IGFBP-1; Insulin-Like Growth Factor Binding Protein 1 - genetics; Insulin-Like Growth Factor Binding Protein 1 - physiology; intrauterinegrowth restriction; Ovary - pathology; Ovary - physiology; polycystic ovarian syndrome; Polycystic Ovary Syndrome - physiopathology; pre-eclampsia; Pregnancy; Reproduction - genetics; Reproduction - physiology; Somatomedins - physiology
• ISSN: 1355-4786; 1460-2369
• DOI: 10.1093/humupd/6.5.495

Insulin-like growth factor-1 (IGFBP-1) is particularly important in human female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.