Role of gut microbiota on intestinal barrier function in acute pancreatitis

Acute pancreatitis (AP) is a common gastrointestinal disorder. Approximately 15%-20% of patients develop severe AP. Systemic inflammatory response syndrome and multiple organ dysfunction syndrome may be caused by the massive release of inflammatory cytokines in the early stage of severe AP, followed...

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Published inWorld journal of gastroenterology : WJG Vol. 26; no. 18; pp. 2187 - 2193
Main Authors Li, Xue-Yang, He, Cong, Zhu, Yin, Lu, Nong-Hua
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 14.05.2020
Subjects
Disease Progression
Gastrointestinal Microbiome - physiology
Humans
Intestinal Mucosa - microbiology
Intestinal Mucosa - pathology
Intestinal Mucosa - physiopathology
Minireviews
Pancreatitis - diagnosis
Pancreatitis - microbiology
Pancreatitis - pathology
Pancreatitis - physiopathology
Permeability
Severity of Illness Index
Gut microbiota
Intestinal barrier
Short-chain fatty acids
Acute pancreatitis
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Summary:Acute pancreatitis (AP) is a common gastrointestinal disorder. Approximately 15%-20% of patients develop severe AP. Systemic inflammatory response syndrome and multiple organ dysfunction syndrome may be caused by the massive release of inflammatory cytokines in the early stage of severe AP, followed by intestinal dysfunction and pancreatic necrosis in the later stage. A study showed that 59% of AP patients had associated intestinal barrier injury, with increased intestinal mucosal permeability, leading to intestinal bacterial translocation, pancreatic tissue necrosis and infection, and the occurrence of multiple organ dysfunction syndrome. However, the real effect of the gut microbiota and its metabolites on intestinal barrier function in AP remains unclear. This review summarizes the alterations in the intestinal flora and its metabolites during AP development and progression to unveil the mechanism of gut failure in AP.
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Author contributions: Li XY and He C conceived and designed the study and wrote the manuscript; Zhu Y and Lu NH made substantial contributions to conception, design and coordination of the study and gave final approval of the version to be published; all authors read and approved the final manuscript.
Corresponding author: Yin Zhu, PhD, Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. zhuyin27@sina.com
Supported by the National Natural Science Foundation of China, No. 81760120 and No. 81960128; and the Key Program of Science and Technology Department of Jiangxi Province, No. 20171BBG70084 and No. 20192ACBL20037.
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v26.i18.2187