Short-Term Water- and Land-Based Exercise Training Comparably Improve Exercise Capacity and Vascular Function in Patients After a Recent Coronary Event: A Pilot Randomized Controlled Trial

• Published in: Frontiers in physiology Vol. 10; p. 903
• Main Authors: Vasić, Danijela, Novaković, Marko, Božič Mijovski, Mojca, Barbič Žagar, Breda, Jug, Borut
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.07.2019
• Subjects: aquatic exercise; cardiac rehabilitation; coronary artery disease; exercise training; myocardial infarction; Physiology; coronary artery disease; aquatic exercise; cardiac rehabilitation; exercise training; myocardial infarction
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2019.00903

We hypothesized that a 2-week twice daily aquatic endurance calisthenics exercise training program: (i) increases aerobic exercise capacity (peak oxygen uptake/ O peak), (ii) improves endothelium-dependent flow-mediated vasodilation (FMD), and (iii) reduces circulating markers of low-grade inflammation and hemostasis, as compared to land-based endurance calisthenics exercise training or no exercise in patients undergoing short-term residential cardiac rehabilitation after a recent coronary artery disease (CAD) event. Patients with a recent myocardial infarction or revascularization procedure were randomized into two interventional groups and a control group. The interventional groups underwent supervised aerobic endurance calisthenics exercise training either in thermo-neutral water or on land at moderate intensity (60-80% of the peak heart rate achieved during symptom-limited graded exercise testing) for 30 min twice daily for 2 weeks (i.e., 24 sessions). The control group was deferred from supervised exercise training for the 2-week duration of the intervention, but was advised low-to-moderate intensity physical activity at home while waiting. At baseline and after the intervention period, all participants underwent estimation of aerobic exercise capacity, brachial artery flow-mediated dilatation (FMD, measured ultrasonographically at rest and during reactive hyperemia after 4.5 min of forearm cuff inflation), markers of cardiac dysfunction (NT-proBNP), inflammation (hsCRP, IL-6, IL-8, IL-10), cell adhesion (ICAM, P-selectin), and hemostasis (fibrinogen, D-dimer). A total of 89 patients (mean age 59.9 ± 8.2 years, 77.5% males, O peak at baseline 14.8 ± 3.5 ml kg min ) completed the study. Both exercise modalities were safe (no significant adverse events recorded) and associated with a significant improvement in O peak as compared to controls: age and baseline O peak-adjusted end-of-study O peak increased to 16.7 (95% CI 16.0-17.4) ml kg min with land-based training ( < 0.001 for change from baseline) and to 18.6 (95% CI 17.9-19.3) ml kg min with water-based training ( < 0.001 for change from baseline), but not in controls (14.9 ml kg min ; 95% CI 14.2-15.6; = 0.775 for change from baseline). FMD also increased in both intervention groups (from 5.5 to 8.8%, < 0.001 with land-based, and from 7.2 to 9.2%, < 0.001 with water-based training, respectively), as compared to controls ( for change 0.629). No significant changes were detected in biomarkers of inflammation, cell adhesion or hemostasis, whereas levels of NT-proBNP (marker of cardiac dysfunction) decreased in the water-based training group ( = 0.07 vs. controls). Endurance calisthenics exercise training in thermo-neutral water is safe, and improves aerobic exercise capacity and vascular function in patients undergoing short-term residential cardiac rehabilitation after a recent CAD event. www.ClinicalTrials.gov, identifier NCT02831829.