Spatiotemporal Regulation of Hsp90-Ligand Complex Leads to Immune Activation

Although heat shock proteins (HSPs) primarily play a pivotal role in the maintenance of cellular homeostasis while reducing extracellular as well as intracellular stresses, their role in immunologically relevant scenarios, including activation of innate immunity as danger signals, antitumor immunity...

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Published inFrontiers in immunology Vol. 7; p. 201
Main Authors Tamura, Yasuaki, Yoneda, Akihiro, Takei, Norio, Sawada, Kaori
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.05.2016
Subjects
Immunology
heat shock protein
toll-like receptor
cross-presentation
autoimmune disease
dendritic cell
danger signal
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Summary:Although heat shock proteins (HSPs) primarily play a pivotal role in the maintenance of cellular homeostasis while reducing extracellular as well as intracellular stresses, their role in immunologically relevant scenarios, including activation of innate immunity as danger signals, antitumor immunity, and autoimmune diseases, is now gaining much attention. The most prominent feature of HSPs is that they function both in their own and as an HSP-ligand complex. We here show as a unique feature of extracellular HSPs that they target chaperoned molecules into a particular endosomal compartment of dendritic cells, thereby inducing innate and adaptive immune responses via spatiotemporal regulation.
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Edited by: Stuart Keith Calderwood, Harvard Medical School, USA
Specialty section: This article was submitted to Immunotherapies and Vaccines, a section of the journal Frontiers in Immunology
Reviewed by: Katsuyuki Yui, Nagasaki University, Japan; Elizabeth Ann Repasky, Roswell Park Cancer Institute, USA
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2016.00201