Anti-Immune Strategies of Pathogenic Fungi

Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the imm...

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Published inFrontiers in cellular and infection microbiology Vol. 6; p. 142
Main Authors Marcos, Caroline M, de Oliveira, Haroldo C, de Melo, Wanessa de Cássia M Antunes, da Silva, Julhiany de Fátima, Assato, Patrícia A, Scorzoni, Liliana, Rossi, Suélen A, de Paula E Silva, Ana C A, Mendes-Giannini, Maria J S, Fusco-Almeida, Ana M
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.11.2016
Subjects
Animals
fungal immune evasion
fungal immune evasion mechanism
fungal immune evasion mechanisms
Fungi - immunology
Fungi - pathogenicity
host-pathogen interaction
Host-Pathogen Interactions
Humans
Immune Evasion
immune response
Microbiology
pathogenic fungi
host-pathogen interaction
fungal immune evasion mechanisms
fungal infection
pathogenic fungi
immune response
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Summary:Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow their survival, colonization and spread to different sites of infection. Consequently, the establishment of a successful infectious process is closely related to the ability of the pathogen to modulate attack by the immune system. Most strategies employed to subvert or exploit the immune system are shared among different species of fungi. In this review, we summarize the main strategies employed for immune evasion by some of the major pathogenic fungi.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Edited by: Michail Lionakis, National Institute of Allergy and Infectious Diseases, USA
Reviewed by: Georgios Chamilos, University of Crete, Greece; Michal Adam Olszewski, University of Michigan, USA
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2016.00142