Immune Evasion Strategies of Glioblastoma

Glioblastoma (GBM) is the most devastating brain tumor, with associated poor prognosis. Despite advances in surgery and chemoradiation, the survival of afflicted patients has not improved significantly in the past three decades. Immunotherapy has been heralded as a promising approach in treatment of...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in surgery Vol. 3; p. 11
Main Authors Razavi, Seyed-Mostafa, Lee, Karen E., Jin, Benjamin E., Aujla, Parvir S., Gholamin, Sharareh, Li, Gordon
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.03.2016
Subjects
cancer immunotherapy
Glioblastoma
Immune Evasion
Immune System
Immunosuppression
Surgery
immune system
immunosuppression
glioblastoma
immune evasion
cancer immunotherapy
Online AccessGet full text

Cover

More Information
Summary:Glioblastoma (GBM) is the most devastating brain tumor, with associated poor prognosis. Despite advances in surgery and chemoradiation, the survival of afflicted patients has not improved significantly in the past three decades. Immunotherapy has been heralded as a promising approach in treatment of various cancers; however, the immune privileged environment of the brain usually curbs the optimal expected response in central nervous system malignancies. In addition, GBM cells create an immunosuppressive microenvironment and employ various methods to escape immune surveillance. The purpose of this review is to highlight the strategies by which GBM cells evade the host immune system. Further understanding of these strategies and the biology of this tumor will pave the way for developing novel immunotherapeutic approaches for treatment of GBM.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: William Tupper Couldwell, University of Utah, USA
Specialty section: This article was submitted to Neurosurgery, a section of the journal Frontiers in Surgery
Reviewed by: Hiroki Toda, Kitano Hospital, Japan; A. Samy Youssef, University of Colorado, USA
ISSN:2296-875X
2296-875X
DOI:10.3389/fsurg.2016.00011