Laboratory Diagnosis of Respiratory Tract Infections in Children – the State of the Art

In the pediatric population, respiratory infections are the most common cause of physician visits. Although many respiratory illnesses are self-limiting viral infections that resolve with time and supportive care, it can be critical to identify the causative pathogen at an early stage of the disease...

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Published inFrontiers in microbiology Vol. 9; p. 2478
Main Authors Das, Shubhagata, Dunbar, Sherry, Tang, Yi-Wei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.10.2018
Subjects
Microbiology
molecular diagnostics
pediatric population
respiratory infection diagnosis
respiratory tract infection
respiratory virus
molecular diagnostics
pediatric population
respiratory tract infection
respiratory virus
respiratory infection diagnosis
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Summary:In the pediatric population, respiratory infections are the most common cause of physician visits. Although many respiratory illnesses are self-limiting viral infections that resolve with time and supportive care, it can be critical to identify the causative pathogen at an early stage of the disease in order to implement effective antimicrobial therapy and infection control. Over the last few years, diagnostics for respiratory infections have evolved substantially, with the development of novel assays and the availability of updated tests for newer strains of pathogens. Newer laboratory methods are rapid, highly sensitive and specific, and are gradually replacing the conventional gold standards, although the clinical utility of these assays is still under evaluation. This article reviews the current laboratory methods available for testing for respiratory pathogens and discusses the advantages and disadvantages of each approach.
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Edited by: Qiwei Zhang, Southern Medical University, China
Reviewed by: Vitali Sintchenko, University of Sydney, Australia; Timothy James Wells, The University of Queensland, Australia
This article was submitted to Infectious Diseases, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2018.02478