Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk between different bone-resident cells. Osteobl...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 10; p. 1901
Main Authors Pieters, Bartijn C H, Cappariello, Alfredo, van den Bosch, Martijn H J, van Lent, Peter L E M, Teti, Anna, van de Loo, Fons A J
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.08.2019
Subjects
alarmins
bone homeostasis
exosomes
extracellular vesicles
Immunology
macrophages
bone homeostasis
macrophages
extracellular vesicles
exosomes
alarmins
Online AccessGet full text

Cover

More Information
Summary:Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk between different bone-resident cells. Osteoblasts and osteoclasts are capable of releasing various types of extracellular vesicles that promote both osteogenesis, as well as, osteoclastogenesis, maintaining bone homeostasis. However, the contribution of immune cell-derived extracellular vesicles in bone homeostasis remains largely unknown. Recent proteomic studies showed that alarmins are abundantly present in/on macrophage-derived EVs. In this review we will describe these alarmins in the context of bone matrix regulation and discuss the potential contribution macrophage-derived EVs may have in this process.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: David Stephen Pisetsky, Duke University, United States; Joost Joe Oppenheim, National Cancer Institute at Frederick, United States
Edited by: Daniela Bosisio, University of Brescia, Italy
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.01901