Research Progress of Circular RNA in Gastrointestinal Tumors

circular RNA (circRNA) is a closed ring structure formed by cyclic covalent bonds connecting the 5'-end and 3'-end of pre-mRNA. circRNA is widely distributed in eukaryotic cells. Recent studies have shown that circRNA is involved in the pathogenesis and development of multiple types of dis...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in oncology Vol. 11; p. 665246
Main Authors Fang, Na, Ding, Guo-Wen, Ding, Hao, Li, Juan, Liu, Chao, Lv, Lu, Shi, Yi-Jun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.04.2021
Subjects
circRNA
circular RNA
gastrointestinal tumors
miRNA
Oncology
pre-mRNA
miRNA
pre-mRNA
circRNA
circular RNA
gastrointestinal tumors
Online AccessGet full text

Cover

More Information
Summary:circular RNA (circRNA) is a closed ring structure formed by cyclic covalent bonds connecting the 5'-end and 3'-end of pre-mRNA. circRNA is widely distributed in eukaryotic cells. Recent studies have shown that circRNA is involved in the pathogenesis and development of multiple types of diseases, including tumors. circRNA is specifically expressed in tissues. And the stability of circRNA is higher than that of linear RNA, which can play biological roles through sponge adsorption of miRNA, interaction with RNA binding protein, regulation of gene transcription, the mRNA and protein translation brake, and translation of protein and peptides. These characteristics render circRNAs as biomarkers and therapeutic targets of tumors. Gastrointestinal tumors are common malignancies worldwide, which seriously threaten human health. In this review, we summarize the generation and biological characteristics of circRNA, molecular regulation mechanism and related effects of circRNA in gastrointestinal tumors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Hamed Mirzaei, Kashan University of Medical Sciences, Iran; Shuji Ogino, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, United States
This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology
Edited by: Zsolt Kovács, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.665246