Mesenchymal cell differentiation during lymph node organogenesis

Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interacti...

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Published inFrontiers in immunology Vol. 3; p. 381
Main Authors Brendolan, Andrea, Caamaño, Jorge H
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2012
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Abstract Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen-loaded dendritic cells and lymphocytes expressing their specific receptor as well as B-T cell interactions that are at the core of long lasting adaptive immune responses. Lymph nodes develop during embryogenesis as a result of a series of cross-talk interactions between a hematopoietically derived cell lineage called lymphoid tissue inducer cells and stromal cells of mesenchymal origin to form the anlagen of these organs. This review will present an overview of the different signaling pathways and maturation steps that mesenchymal cells undergo during the process of lymph node formation such as cell specification, priming, and maturation to become lymphoid tissue stromal organizer cells.
AbstractList Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen-loaded dendritic cells and lymphocytes expressing their specific receptor as well as B-T cell interactions that are at the core of long lasting adaptive immune responses. Lymph nodes develop during embryogenesis as a result of a series of crosstalk interactions between a hematopoietically derived cell lineage called lymphoid tissue inducer cells and stromal cells of mesenchymal origin to form the anlagen of these organs. This minireview will present an overview of the different signaling pathways and maturation steps that mesenchymal cells undergo during the process of lymph node formation such as cell specification, priming and maturation to become lymphoid tissue stromal organizer cells.
Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen-loaded dendritic cells and lymphocytes expressing their specific receptor as well as B-T cell interactions that are at the core of long lasting adaptive immune responses. Lymph nodes develop during embryogenesis as a result of a series of cross-talk interactions between a hematopoietically derived cell lineage called lymphoid tissue inducer cells and stromal cells of mesenchymal origin to form the anlagen of these organs. This review will present an overview of the different signaling pathways and maturation steps that mesenchymal cells undergo during the process of lymph node formation such as cell specification, priming, and maturation to become lymphoid tissue stromal organizer cells.
Author Caamaño, Jorge H
Brendolan, Andrea
AuthorAffiliation 1 Division of Molecular Oncology, San Raffaele Scientific Institute Milan, Italy
2 School of Immunity and Infection, Institute for BioMedical Research-Medical Research Council Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham Birmingham, UK
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/23248630$$D View this record in MEDLINE/PubMed
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Keywords lymphotoxin beta receptor
NF-κB
stromal cells
lympho-mesenchymal interactions
lymphoid tissues
Language English
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Edited by: Matthew Griffin, National University of Ireland, Ireland
This article was submitted to Frontiers in Antigen Presenting Cell Biology, a specialty of Frontiers in Immunology.
Reviewed by: Tom Cupedo, Erasmus University Medical Center, Netherlands; Christopher G Mueller, Centre National de la Recherche Scientifique, France
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SubjectTerms cell-cell interaction
Immunology
Lymphoid Tissue
Lymphotoxin beta Receptor
NF-kappa B
Stromal Cells
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Title Mesenchymal cell differentiation during lymph node organogenesis
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