Mesenchymal cell differentiation during lymph node organogenesis
Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interacti...
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Published in | Frontiers in immunology Vol. 3; p. 381 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
01.01.2012
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Subjects | |
Online Access | Get full text |
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Summary: | Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen-loaded dendritic cells and lymphocytes expressing their specific receptor as well as B-T cell interactions that are at the core of long lasting adaptive immune responses. Lymph nodes develop during embryogenesis as a result of a series of cross-talk interactions between a hematopoietically derived cell lineage called lymphoid tissue inducer cells and stromal cells of mesenchymal origin to form the anlagen of these organs. This review will present an overview of the different signaling pathways and maturation steps that mesenchymal cells undergo during the process of lymph node formation such as cell specification, priming, and maturation to become lymphoid tissue stromal organizer cells. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Matthew Griffin, National University of Ireland, Ireland This article was submitted to Frontiers in Antigen Presenting Cell Biology, a specialty of Frontiers in Immunology. Reviewed by: Tom Cupedo, Erasmus University Medical Center, Netherlands; Christopher G Mueller, Centre National de la Recherche Scientifique, France |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2012.00381 |