Colorectal obstruction is a potential prognostic factor for stage II colorectal cancer

• Published in: International journal of clinical oncology Vol. 23; no. 6; pp. 1101 - 1111
• Main Authors: Okuda, Yusuke, Shimura, Takaya, Yamada, Tomonori, Hirata, Yoshikazu, Yamaguchi, Ryuzo, Sakamoto, Eiji, Kataoka, Hiromi
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.12.2018; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Cancer Research; Chemotherapy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Colorectal Surgery - adverse effects; Female; Humans; Intestinal Obstruction - diagnosis; Intestinal Obstruction - etiology; Male; Medical prognosis; Medicine; Medicine & Public Health; Middle Aged; Morbidity; Multivariate analysis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - etiology; Oncology; Original Article; Prognosis; Retrospective Studies; Surgery; Surgical Oncology; Survival; Survival Rate; Prognostic factor; Stage II; Colorectal cancer; Colorectal obstruction
• ISSN: 1341-9625; 1437-7772
• DOI: 10.1007/s10147-018-1307-2

Background Obstructive colorectal cancer (CRC) is an emergency situation with high morbidity and mortality, but long-term outcomes of stage II/III obstructive CRC remain unclear. The aim of this study was to evaluate prognostic factors, including colorectal obstruction. Methods Data were retrospectively reviewed from consecutive patients with stage II/III CRC who underwent curative surgery between January 2007 and December 2011 at two Japanese institutions. We analyzed overall survival (OS) and relapse-free survival (RFS), according to various prognostic factors including colorectal obstruction. Results In total, 979 patients with stage II/III CRC were identified for this study. Among these 979 patients, 94 patients showed colorectal obstruction (9.6%). In both stage II and stage III CRCs, colorectal obstruction showed significantly poorer OS and RFS compared to non-obstruction (5-year OS, obstruction vs. non-obstruction, stage II: 65.9 vs. 86.5%, P  = 0.002; stage III: 55.9 vs. 73.6%, P  = 0.007) (5-year RFS, obstruction vs. non-obstruction, stage II: 59.2 vs. 77.8%, P  = 0.008; stage III 31.3 vs. 56.3%, P  = 0.001). Multivariate analysis demonstrated colorectal obstruction as a significant independent and poor prognostic factor in terms of both OS (hazard ratio (HR) 2.469; 95% CI 1.339–4.545; P  = 0.004) and RFS (HR 1.992; 95% CI 1.160–3.425; P  = 0.012) for stage II CRC, as well as pT4 stage. On multivariate analysis for stage III CRC, colorectal obstruction was a significant predictor of poor RFS (HR 1.626; 95% CI 1.070–2.469; P  = 0.023), but not poor OS. Conclusions Colorectal obstruction is an independent poor prognostic factor for stage II CRC. Adjuvant chemotherapy might be feasible for stage II CRC with colorectal obstruction.