Altered Gut Microbiota Composition Is Associated With Back Pain in Overweight and Obese Individuals

Back pain is the leading cause of disability worldwide and is associated with obesity and chronic low-grade inflammation. Alterations in intestinal microbiota may contribute to the pathogenesis of back pain through metabolites affecting immune and inflammatory responses. We compared the gut microbio...

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Published inFrontiers in endocrinology (Lausanne) Vol. 11; p. 605
Main Authors Dekker Nitert, Marloes, Mousa, Aya, Barrett, Helen L, Naderpoor, Negar, de Courten, Barbora
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 02.09.2020
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Summary:Back pain is the leading cause of disability worldwide and is associated with obesity and chronic low-grade inflammation. Alterations in intestinal microbiota may contribute to the pathogenesis of back pain through metabolites affecting immune and inflammatory responses. We compared the gut microbiota composition in a cohort of 36 overweight or obese individuals with or without self-reported back pain in the preceding month. Participants were characterized for anthropometry; bone health; metabolic health; inflammation; dietary intake; and physical activity. Demographic, clinical, biochemical characteristics, diet and physical activity were similar between participants with ( = 14) or without ( = 22) back pain. Individuals with back pain had a higher abundance of the genera ( = 0.0008; FDR = 0.027) ( = 0.0098; FDR = 0.17), and ( = 0.02; FDR = 0.27) than those without back pain. abundance remained higher in individuals with back pain in the past 2 weeks, 6 months, and 1 year. was positively correlated with BMI (rho = 0.35, = 0.03), serum adipsin (rho = 0.33, = 0.047), and serum leptin (rho = 0.38, = 0.02). Our findings suggest that back pain is associated with altered gut microbiota composition, possibly through increased inflammation. Further studies delineating the underlying mechanisms may identify strategies for lowering abundance to treat back pain.
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Edited by: Sandhya Srikant Visweswariah, Indian Institute of Science (IISc), India
These authors have contributed equally to this work and share first authorship
Reviewed by: Katherine Samaras, St Vincent's Hospital Sydney, Australia; Michael Horowitz, University of Adelaide, Australia
This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.00605