Environmental Stressors on Skin Aging. Mechanistic Insights

The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particul...

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Published inFrontiers in pharmacology Vol. 10; p. 759
Main Authors Parrado, Concepcion, Mercado-Saenz, Sivia, Perez-Davo, Azahara, Gilaberte, Yolanda, Gonzalez, Salvador, Juarranz, Angeles
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 09.07.2019
Subjects
air pollutant
inflammation
oxidative stress
Pharmacology
photo-pollution
skin aging
skin aging
inflammation
air pollutant
oxidative stress
photo-pollution
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Summary:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. This review addresses the impact of environmental stressors on skin aging, especially those related to general and specific external factors (lifestyle, occupation, pollutants, and light exposure). More specifically, we have evaluated ambient air pollution, household air pollutants from non-combustion sources, and exposure to light (ultraviolet radiation and blue and red light). We approach the molecular pathways involved in skin aging and pathology as a result of exposure to these external environmental stressors. Finally, we reflect on how components of environmental stress can interact with ultraviolet radiation to cause cell damage and the critical importance of knowing the mechanisms to develop new therapies to maintain the skin without damage in old age and to repair its diseases.
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Reviewed by: Zorica Janjetovic, University of Alabama at Birmingham, United States; Anna A. Brozyna, Nicolaus Copernicus University, Poland
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
Edited by: Andrzej T. Slominski, University of Alabama at Birmingham, United States
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2019.00759